کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10959258 | 1100411 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy? Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?](/preview/png/10959258.png)
چکیده انگلیسی
It is increasingly recognized that the non-neoplastic stromal compartment in most solid cancers plays an active role in tumor proliferation, invasion and metastasis. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types in the tumor stroma, and these cells are pro-tumorigenic. Evidence that CAFs are epigenetically and possibly also genetically distinct from normal fibroblasts is beginning to define these cells as potential targets of anti-cancer therapy. Here, we review the cell-of-origin and molecular biology of CAFs, arguing that such knowledge provides a rational basis for designing therapeutic strategies to coordinately and synergistically target both the stromal and malignant epithelial component of human cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 21, Issue 1, February 2010, Pages 2-10
Journal: Seminars in Cell & Developmental Biology - Volume 21, Issue 1, February 2010, Pages 2-10
نویسندگان
Tamas A. Gonda, Andrea Varro, Timothy C. Wang, Benjamin Tycko,