کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10959563 | 1100461 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beyond proliferation-cell cycle control of neuronal survival and differentiation in the developing mammalian brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Cell cycle proteins are critical regulators of proliferation in dividing cells. Paradoxically, accumulating evidence supports the view that core components of the cell cycle also play key roles in the development of terminally differentiated postmitotic neurons. Distinct cell cycle proteins including cell cycle-dependent kinases may contribute to naturally occurring programmed neuronal cell death in the developing mammalian brain. In addition, recent studies have uncovered a novel role for the cell cycle-associated ubiquitination machinery in the control of axonal growth and patterning in the developing brain. The underlying molecular mechanisms regulating these distinct cell cycle-based developmental events in neurons are just beginning to be understood.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 16, Issue 3, June 2005, Pages 439-448
Journal: Seminars in Cell & Developmental Biology - Volume 16, Issue 3, June 2005, Pages 439-448
نویسندگان
Esther B.E. Becker, Azad Bonni,