کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10959903 | 1100591 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas Expression of novel organic cation/carnitine transporter (OCTN2) in the mouse pancreas](/preview/png/10959903.png)
چکیده انگلیسی
Among the organic cation transporters, OCTN2 is identified as the most important carnitine transporter owing to the ability to transport carnitine. Although the OCTN2 is previously found in various tissues, there have been no reports showing the OCTN2 in the pancreas. In this study, we examined the expression and localization of OCTN2 in the mouse pancreas by the aid of an in situ hybridization technique and immunohistochemistry with anti-OCTN2 antibody. As a result, the OCTN2 expression was found in the A-cells for the first time. OCTN2 was not expressed in B-cells, notwithstanding that the metabolism of long-chain fatty acids, which are transported into the mitochondria with the help of carnitine, was expected for fatty acid-stimulated insulin secretion. Thus, this study suggests the possibility of carnitine uptake in the pancreatic A-cells through OCTN2 and implies the presence of carnitine transporter(s) other than OCTN2 in the B-cell.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tissue and Cell - Volume 37, Issue 4, August 2005, Pages 309-315
Journal: Tissue and Cell - Volume 37, Issue 4, August 2005, Pages 309-315
نویسندگان
Saori Kai, Kazumichi Yakushiji, Masamichi Yamauchi, Chizuru Ito, Masamichi Kuwajima, Yukio Osada, Kiyotaka Toshimori,