Bioavailability and Tolerability of Topical and Oral Diclofenac Sodium Administration in Healthy Ponies

Samples collected before and at 0, 24, 48, 72, 96, 120, and 144 hours after starting treatment were also used for complete blood cell count, biochemistry, and coagulation profile. A difference was found between groups I and II regarding prothrombin time, activated partial thromboplastin time, fibrinogen, packed cell volume, hemoglobin, red and white blood cell count, polymorphonuclear cells, band cells, lymphocytes, eosinophils, and alkaline phosphatase. Similar results were found between groups II and III; however, activated partial thromboplastin time did not differ. Plasma concentration of diclofenac sodium in group II was higher than that in group I. Synovial diclofenac concentration was higher than minimal therapeutic levels in groups I and II.