کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10962286 1102358 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure and function of the tuberculous lung: Considerations for inhaled therapies
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Structure and function of the tuberculous lung: Considerations for inhaled therapies
چکیده انگلیسی
Inhaled therapies for pulmonary tuberculosis are in development and appear promising at first look. A fundamental premise of such therapy is efficient delivery of drug at high concentrations to the active disease site, while minimizing systemic delivery. This assumes that inhaled drug will actually reach the diseased lung, which while intuitive for healthy lungs, may be untrue for diseased lungs with abnormal structure or function. This review discusses the structural and functional aspects of respiratory physiology that are likely to impact local drug delivery and presents the available evidence on how this pertains to tuberculous lungs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 91, Issue 1, January 2011, Pages 67-70
نویسندگان
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