کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971707 | 1106514 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of essential B cell genes and immunoglobulin isotypes suggests active development and gene recombination during equine gestation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mRNART-PCRB cell ontogenyM-MuLVcDNA - cDNAComplementary DNA - DNA تکمیلیdNTPS - DNTPSmessenger RNA - RNA messengerHorse - اسبEST - استimmunoglobulin - ایمونوگلوبولینimmunoglobulins - ایمونوگلوبولین هاFoal - فالreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوسMoloney murine leukemia virus - ویروس لوئی موش MoloneyHumoral response - پاسخ هومورال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Many features of the equine immune system develop during fetal life, yet the naïve or immature immune state of the neonate renders the foal uniquely susceptible to particular pathogens. RT-PCR and immunohistochemical experiments investigated the progressive expression of developmental B cell markers and immunoglobulins in lymphoid tissues from equine fetus, pre-suckle neonate, foal, and adult horses. Serum IgM, IgG isotype, and IgA concentrations were also quantified in pre-suckle foals and adult horses. The expression of essential B cell genes suggests active development and gene recombination during equine gestation, including immunoglobulin isotype switching. The corresponding production of IgM and IgG proteins is detectable in a limited scale at birth. Although the equine neonate humoral response seems competent, B cell activation factors derived from antigen presenting cells and T cells may control critical developmental regulation and immunoglobulin production during the initial months of life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 33, Issue 9, September 2009, Pages 1027-1038
Journal: Developmental & Comparative Immunology - Volume 33, Issue 9, September 2009, Pages 1027-1038
نویسندگان
Rebecca L. Tallmadge, Kristin McLaughlin, Erica Secor, Diana Ruano, Mary Beth Matychak, M. Julia B.F. Flaminio,