Norepinephrine regulates prophenoloxidase system-related parameters and gene expressions via α- and β-adrenergic receptors in Litopenaeus vannamei

► NE down-regulated LGBP and proPO-II genes transcription of haemocytes via α1-ARs. ► NE down-regulated proPO-I genes transcription of haemocytes via β1-ARs. ► NE down-regulated SP and PE genes transcription via α1- and β1-ARs. ► NE depressed PO activity of haemocytes via α1- and β1-ARs.