Molecular characterization and expression analysis of IκB from Haliotis discus discus

► HdIκB possessed conserved motifs, PEST domains, ankyrin repeats. ► HdIκB revealed ubiquitous expression in the analyzed tissues. ► Transcriptional profiling post poly I:C challenge in hemocytes showed up-regulation. ► Transcriptional profiling post LPS and VHSV challenge in hemocytes showed induction. ► mRNA profiling post bacterial challenge in hemocytes revealed up-regulation.