کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10982225 1108090 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communication: Antiproliferative effect of wild Lactobacillus strains isolated from fermented foods on HT-29 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Short communication: Antiproliferative effect of wild Lactobacillus strains isolated from fermented foods on HT-29 cells
چکیده انگلیسی
In vitro studies, animal models, epidemiology, and human intervention studies provide evidence that some lactic acid bacteria can reduce the risk of certain cancers. In this study, heat-killed bacterial cells, genomic DNA, and cell wall of 7 wild Lactobacillus strains isolated from traditional fermented foods in western China were tested in vitro for cytotoxicity on colonic cancer cell line HT-29 by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The heat-killed bacterial cells, genomic DNA, and cell wall of the 7 strains exhibited direct antiproliferative activities against HT-29 cells. Among the strains, the cellular components of Lactobacillus coryniformis ssp. torquens T3L exerted marked antiproliferative activities against HT-29 cells. The maximum inhibition rates of HT-29 cells by the heat-killed bacterial cells (1 × 107 cfu/mL), cell wall (20 μg of protein/mL) and genomic DNA (100 μg/mL) of L. coryniformis ssp. torquens T3L were 30, 44.9, and 35.9%, respectively. The results indicate that the heat-killed bacterial cells, cell wall, and genomic DNA of the 7 wild Lactobacillus strains could inhibit the growth of HT-29 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dairy Science - Volume 93, Issue 6, June 2010, Pages 2362-2366
نویسندگان
, , , , , , , , ,