کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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10988 | 711 | 2005 | 10 صفحه PDF | دانلود رایگان |
Degeneration of the intervertebral disc is the most common cause of back pain. In case of early stage degenerative disc disease or traumatic herniations, a suitable treatment may be to replace the nucleus pulposus, preserving the annulus fibrosus. Eight new hydrogel biomaterials were prepared and studied for their potential as a nucleus replacement. The hydrogels were designed according to the following criteria: (i), they should exhibit adequate radiopacity; (ii), they should be non-cytotoxic; (iii), implantation in the dry state and subsequent swelling in situ to fill the entire nucleus cavity; (iv), after swelling they should match the physical–mechanical properties of the native nucleus. The approach was to use copolymers consisting of 2-(4′-iodobenzoyl)-oxo-ethyl methacrylate (4IEMA) and a hydrophilic building block (either N-vinyl-2-pyrrolidinone (NVP) or 2-hydroxyethyl methacrylate (HEMA)); 4 copolymers of NVP/4IEMA and 4 copolymers of HEMA/4IEMA in different compositions (5, 10, 15 and 20 mol% 4IEMA).The study comprised 1H-NMR analysis of the copolymerization reaction NVP+4IEMA. Furthermore, the copolymers were studied with respect to their swelling behavior, mechanical properties, cytotoxicity in vitro and X-ray contrast. Hydrogels with 5 mol% 4IEMA appear to meet all criteria: they are non-cytotoxic, have adequate physical–mechanical properties and feature sufficient radiopacity in a realistic model. The potential implications of these new results with respect to treatment of degenerative disc disease are discussed briefly.
Journal: Biomaterials - Volume 26, Issue 33, November 2005, Pages 6674–6683