The effect of buprenorphine on isoflurane minimum alveolar concentration in dogs

Buprenorphine at 0.01, 0.05, and 0.1 mg kg−1 significantly decreased ISOMAC in dogs at 141 minutes but not at 342 minutes. When using BUP for MAC reduction re-dosing may be required for procedures of long duration, and there may be no advantage to using the 0.1 mg kg−1 dose.