کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11001583 | 933558 | 2019 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tug-of-war in motor proteins and the emergence of Lévy walk
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
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چکیده انگلیسی
In recent experiment, transport of mRNA-protein complex in neurons has been observed to follow a truncated Lévy walk behavior. We have theoretically studied a random walk model based on majority rule. At a given instant, the moving direction of a cargo is determined by motor coordination mediated by a tug-of-war mechanism between two kinds of competing motor proteins. We have demonstrated that the run-time distribution P(t) for unidirectional transport of a cargo can be described by a truncated Lévy walk P(t)âtâ3â2eâγut with γu being the unbinding rate of a motor protein from microtubule. The mean squared displacement of a cargo changes from super-diffusive behavior ãX2ãât2 for t<γuâ1 to normal diffusion ãX2ãât for t>γuâ1. By considering the correlation effect in binding of a motor protein to microtubule, we have shown that Lévy walk behavior of P(t)âtâ3â2 persists robustly against correlation simply adding a finite cutoff time γbâγc2 with γc representing the amount of correlation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 515, 1 February 2019, Pages 65-71
Journal: Physica A: Statistical Mechanics and its Applications - Volume 515, 1 February 2019, Pages 65-71
نویسندگان
Kyungsun Moon, Hyungseok Chad Moon,