کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11001669 | 1007993 | 2019 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of antimicrobial peptide-grafted graphene oxide nanosheets with high antimicrobial efficacy
ترجمه فارسی عنوان
سنتز نانو ذرات اکسید گرافن با پپتید ضد میکروبی با اثربخشی ضد میکروبی بالا
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کلمات کلیدی
اکسید گرافن، پپتیدهای ضد میکروبی، نانوساختار جذب،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
Graphene nanomaterials have rapidly developed in recent years. However, its antimicrobial activity does not achieve satisfactory effect. During the past years, it has been found that antimicrobial peptides (AMP) have a good inhibitory effect on pathogenic microbes. In this study, we synthesized AMP-grafted graphene oxide (GO) nanosheets, i.e., D28@GO, against the pathogens such as Candida albicans and Escherichia coli. Growth inhibition assays showed that D28@GO had strong inhibitory effect against the pathogens and this toxicity contributes to cell membrane damage caused by interaction between D28@GO and macrobiomolecules. In vivo experiments further showed that D28@GO severely suppressed systemic infections of pathogens. This study provides novel light on development of GO-based antimicrobial materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 235, 15 January 2019, Pages 42-45
Journal: Materials Letters - Volume 235, 15 January 2019, Pages 42-45
نویسندگان
Tongtong Ren, Yufan Wang, Qilin Yu, Mingchun Li,