Mannose-conjugated layered double hydroxide nanocomposite for targeted siRNA delivery to enhance cancer therapy

In this work, mannose-conjugated SiO2-coated LDH (Man-SiO2@LDH) nanocomposite has been developed by grafting mannose onto nNH2-SiO2@LDH. This sheet-like Man-SiO2@LDH nanocomposite has resulted in more efficient uptake of siRNA by U2OS cells via receptor-mediated internalization. As a result, CD-siRNA delivered by Man-SiO2@LDH significantly inhibited U2OS cell growth.205