کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11006715 | 1509128 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial
ترجمه فارسی عنوان
پوشش سطحی ضد باکتری جدید مرتبط با سیتستین به طور قابل توجهی مانع از کلونیزاسیون باکتری های بینی دندان های سیلیکونی بینی در مرحله یک آزمایش قبل از آزمایش
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کلمات کلیدی
پوشش ضد باکتری، لیگاند سیستین، اتصال چاق کننده، محاکمه فاز 1،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Ventilator associated pneumonia and sepsis are frequent complications in neonatal care. Bacterial colonization of medical devices and interfaces used for respiratory support may contribute by functioning as a bacterial reservoir seeding bacteria into airways. We have developed an antibacterial surface coating based on a cysteine ligand covalently coupled via a spacer to a carboxylic backbone layer on an acrylic acid grafted silicone surface. This coating was applied on a commercially available nasal prong and the antibacterial effect was evaluated both in vitro and in vivo in a first-in-human phase 1 trial. The coated nasal prongs had strong antibacterial activity against both Gram-negative and Gram-positive bacteria in vitro. In a randomized pre-clinical trial study of 24â¯+â¯24 healthy adult volunteers who carried coated or non-coated nasal prongs for 18â¯h, a 10log difference in mean bacterial colonization of 5.82 (pâ¯<â¯0.0001) was observed. These results show that this coating technique can prevent colonization by the normal skin and mucosal flora, and thus represent a promising novel technology for reduction of medical device-associated hospital acquired infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 93, 1 December 2018, Pages 782-789
Journal: Materials Science and Engineering: C - Volume 93, 1 December 2018, Pages 782-789
نویسندگان
Jacob Odeberg, Anders Wirsén, Ã
ke Norberg, Jakob Frie, Gordana Printz, Hugo Lagercrantz, Gudmundur H. Gudmundsson, Birgitta Agerberth, Baldvin Jonsson,