کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11007638 | 1543947 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The association between ACE I/D polymorphism and the risk of Alzheimer's disease in Lebanon
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
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چکیده انگلیسی
The insertion/deletion (I/D) polymorphism in Angiotensin converting enzyme (ACE) has been extensively studied as candidate gene for Alzheimer's disease (AD). In this study, the possibility of such an association was investigated in 83 patients diagnosed with AD and 80 matched controls from Lebanese origin. ACE I/D genotypes differed significantly between affected individuals and controls. In addition, ACE I allele and female gender were positively associated with increased risk of AD (O.Râ¯=â¯1.7, Pâ¯=â¯.02 and O.Râ¯=â¯4.2, Pâ¯=â¯.001, respectively). Furthermore, ACE I/D interacted with gender to influence the risk of AD (ORâ¯=â¯1.67, Pâ¯=â¯.001). When stratified according to gender and AD status, ACE I/D distribution varied significantly between AD and controls in women (Pâ¯=â¯.05) but not in men (Pâ¯=â¯.47). In conclusion, our study suggests that ACE I allele and female gender are associated with increased risk of AD in the Lebanese population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Meta Gene - Volume 18, December 2018, Pages 191-194
Journal: Meta Gene - Volume 18, December 2018, Pages 191-194
نویسندگان
Said El Shamieh, Fatima Saleh, Niveen Masri, Hana M. Fakhoury, Rajaa Fakhoury,