کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11009504 | 1826478 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The associated volumes of sub-cortical structures and cognitive domain in patients of Mild Cognitive Impairment
ترجمه فارسی عنوان
حجم مرتبط ساختارهای زیر قشر و دامنه شناختی در بیماران مبتلا به اختلال شناختی خفیف
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کلمات کلیدی
NSAT2 weighted imagingLMTVCTAVLTT2WIIADLBNTVSTCDTSFTNPIDSTMoCAWMHDSM-VADLTMTAFTCDRMMSEFOVTrail Making Test - آزمایش تستmild cognitive impairment - اختلال شناختی خفیفMontreal Cognitive Assessment - ارزیابی شناختی مونترالClinical Dementia Rating - امتیاز دهی بالینیcornu ammonis - بال آمونAlzheimer’s disease - بیماری آلزایمرBoston Naming Test - تست نامگذاری بوستونauditory verbal learning test - تست یادگیری کلامی شنواییCognitive domain - دامنه شناختیecho time - زمان اکوRepetition time - زمان تکرارClock Drawing Test - ساعت رسم تستInstrumental Activities of Daily Living - فعالیت های ابزار زندگی روزمرهActivities of daily living - فعالیت های روزمره زندگیwhite matter hyperintensity - ماده تاریک ماده سفیدMini-Mental State Examination - معاینه دولتی مینی روانشناسیHamilton anxiety rating scale - مقیاس درجه اضطراب همیلتونHamilton Depression Rating Scale - مقیاس رتبه بندی افسردگی همیلتونField of view - میدان دیدHAMA - هماHAMD - همدنMCI - همراه اولNeuropsychiatric Inventory - پرسشنامه نوروپسیتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
This study aimed to explore the relationship between sub-cortical structures alterations and the cognitive domains in Mild Cognitive Impairment (MCI) patients, expected to find identifying sub-cortical structure markers of MCI progression to dementia. A total of 67 MCI patients (8 subjects refused to follow up) were recruited, who were divided into 21 stable MCI (sMCI) and 38 progress MCI (pMCI), according to cognitive assays. FreeSurfer software was used to perform volumetric measurements of the sub-cortical structures from 3.0â¯T magnetic resonance scans. Data revealed that pMCI subjects had lower scores in memory, language, executive and visual spatial compared with sMCI subjects. Compared with the sMCI group, the volume of the left thalamus, bilateral hippocampus, corpus callosum posterior and corpus callosum central was smaller in pMCI subjects. Partial correlation and general linear regression analysis showed that the left hippocampus was predicted region for memory, left thalamus was predicted region for language, executive and visual spatial. These current results suggest that the volumes of sub-cortical structures in stable MCI and progress MCI patients were heterogeneous. Among these regions, the left hippocampus was predicted region for memory, left thalamus was predicted region for language, executive and visual spatial, suggesting that these structures might be important for detecting the subtle effects of MCI patients' cognitive domain or to assess the effectiveness of therapeutic intervention for MCI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 56, October 2018, Pages 56-62
Journal: Journal of Clinical Neuroscience - Volume 56, October 2018, Pages 56-62
نویسندگان
Lai Qian, Renyuan Liu, Ruomeng Qin, Hui Zhao, Yun Xu,