کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11010939 1804489 2019 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiochemical characteristics and bone/cartilage tissue engineering potentialities of protein-based macromolecules - A review
ترجمه فارسی عنوان
ویژگی های فیزیولوژیکی و توانایی های مهندسی بافت های بافتی و غضروف ماکرومولکول های پروتئینی - بررسی
کلمات کلیدی
ماکرومولکول های پروتئینی، بیومارکرهای، مهندسی بافت، ویژگی های مورد نیاز، زیست سازگاری، استئوسنتزی، داربست های متخلخل، چاپ سه بعدی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Protein-based macromolecules such as keratin, silk fibroin, collagen, gelatin, and fibrin have emerged as potential candidate materials with unique structural and functional characteristics. Despite many advantages, the development of tissue-engineered constructs that can match the biological context of real tissue matrix remains a challenge in tissue engineering (TE). The tissue-engineered constructs should also support vascularization. Protein-based macromolecules, in pristine or combine form, provide a promising platform to engineer constructs with unique design and functionalities which are highly essential for an appropriate stimulation and differentiation of cells in a specific TE approach. However, much work remains to be undertaken with particular reference to in-depth interactions between constructed cues and target host tissues. Thus, modern advancements are emphasizing to understand critiques and functionalization of protein-based macromolecule that organize not only cellular activities but also tissue regenerations. In this review, numerous physicochemical, functional, and structural characteristics of protein-based macromolecules such as keratin, silk fibroin, collagen, gelatin, and fibrin are discussed. This review also presents the hope vs. hype phenomenon for tissue engineering. Later part of the review focuses on different requisite characteristics and their role in TE. The discussion presented here could prove highly useful for the construction of scaffolds with requisite features.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 121, January 2019, Pages 13-22
نویسندگان
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