کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11011450 | 1802873 | 2019 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polyglycerol sebacate/chitosan/gelatin nano-composite scaffolds for engineering neural construct
ترجمه فارسی عنوان
داربست نانو کامپوزیت پلی گلیسرول ساباکت / کیتوزان / ژلاتین برای ساختار عصبی مهندسی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
مواد الکترونیکی، نوری و مغناطیسی
چکیده انگلیسی
The aim of this study was designing and fabricating nano-composite scaffolds based on polyglycerol sebacate in order to use in nerve tissue engineering. Semi-crystalline polyglycerol sebacate polymer was synthesized and evaluated by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) methods. The synthesized polyglycerol sebacate was electrospun with chitosan and gelatin at different concentrations under various conditions. The obtained samples were examined using Scanning electron microscopy (SEM) observations; the diameters of fibers were measured via image processing method, and the percentage of scaffolds porosity were obtained as well. Results demonstrated that semi-crystalline polyglycerol sebacate/chitosan/gelatin could be electrospun to produce fibers with the diameter of about 80â¯nm in average. MTT assay were performed using PC12â¯cell line; after 3 days of cell culture, it seems that polyglycerol sebacate/Chitosan/Gelatin nano-composite has potentiality for nerve tissue engineering applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Chemistry and Physics - Volume 222, 15 January 2019, Pages 147-151
Journal: Materials Chemistry and Physics - Volume 222, 15 January 2019, Pages 147-151
نویسندگان
Sanaz Saravani, Mehdi Ebrahimian-Hosseinabadi, Davod Mohebbi-Kalhori,