کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11012038 | 1801637 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
On the low dimensionality of behavioral deficits and alterations of brain network connectivity after focal injury
ترجمه فارسی عنوان
در ابعاد کم نقص رفتاری و تغییرات اتصال شبکه مغز پس از آسیب های کانونی
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کلمات کلیدی
نوروپسیولوژی، سکته مغزی نقشه برداری علائم، اتصال به عملکرد شبکه های مغز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Traditional neuropsychological approaches emphasize the specificity of behavioral deficits and the modular organization of the brain. At the population level, however, there is emerging evidence that deficits are correlated resulting in a low dimensional structure of post-stroke neurological impairments. Here we consider the implications of low dimensionality for the three-way mapping between structural damage, altered physiology, and behavioral deficits. Understanding this mapping will be aided by large-sample studies that apply multivariate models and focus on explained percentage of variance, as opposed to univariate lesion-symptom techniques that report statistical significance. The low dimensionality of behavioral deficits following stroke is paralleled by widespread, yet relatively consistent, changes in functional connectivity (FC), including a reduction in modularity. Both are related to the structural damage to white matter and subcortical grey commonly produced by stroke. We suggest that large-scale physiological abnormalities following a stroke reduce the variety of neural states visited during task processing and at rest, resulting in a limited repertoire of behavioral states.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cortex - Volume 107, October 2018, Pages 229-237
Journal: Cortex - Volume 107, October 2018, Pages 229-237
نویسندگان
Maurizio Corbetta, Joshua S. Siegel, Gordon L. Shulman,