کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11018549 1719090 2018 46 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functions of the CXC ligand family in the pancreatic tumor microenvironment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Functions of the CXC ligand family in the pancreatic tumor microenvironment
چکیده انگلیسی
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. This review highlights the roles of selected CXCLs in the interactions between pancreatic tumor and its stroma, and in CSC phenotypes, which can be used to identify potential treatment targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pancreatology - Volume 18, Issue 7, October 2018, Pages 705-716
نویسندگان
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