Side effects-avoided theranostics achieved by biodegradable magnetic silica-sealed mesoporous polymer-drug with ultralow leakage

Side effects-avoided targeting chemotherapy guided by MRI was achieved based on the multifunctional core-shell nanomedicine with ultralow leakage, where the Fe-doped silica shell acted as the compacted inorganic caps to well seal the anticancer drug doxorubicin into the ordered mesochannels of polymer cores under normal physiological conditions but biodegrade under acidic tumor environments.337