کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025012 | 1701040 | 2019 | 48 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
These results identify the AHR pathway as a potential target for driving targeted immunosuppression in the CNS in the context of atmospheric PM-mediated autoimmune disease. The effects of SRM1649b PM on EAE are dependent on route of exposure, with intranasal treatment reducing severity of EAE and delaying disease onset while oral gavage has no effect. Intranasal SRM1649b PM reduces pathologic T cells in the CNS, specifically Th1 cells and Th1Th17 double positive cells, leading to reduced severity of EAE and AHR-dependent delayed disease onset. Additionally, SRM1649b PM treatment of antigen-specific T cells leads to AHR-dependent increase in percent IL-10 positive cells in vitro. These findings may shed light on the known increase of infection after exposure to atmospheric PM and serve as the first step in identifying components of the AHR pathway responsible for Th1-mediated immunosuppression in response to atmospheric PM exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 168, January 2019, Pages 178-192
Journal: Environmental Research - Volume 168, January 2019, Pages 178-192
نویسندگان
Chelsea A. O'Driscoll, Leah A. Owens, Erica J. Hoffmann, Madeline E. Gallo, Amin Afrazi, Mei Han, John H. Fechner, James J. Schauer, Christopher A. Bradfield, Joshua D. Mezrich,