کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11025532 1678892 2019 40 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxytocin differentially modulates specific dorsal and ventral striatal functional connections with frontal and cerebellar regions
ترجمه فارسی عنوان
اکسی توسین به طور متفاوتی پیوند کارکردی پشتی و جناغی خاص را با مناطق روبرو و مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی
Interactions between oxytocin and the basal ganglia are central in current overarching conceptualizations of its broad modulatory effects on behavior. Whereas evidence from animal models emphasizes the critical role of the ventral striatum in the behavioral effects of oxytocin, region-specific contributions of the basal ganglia have not been systematically explored in humans. The present study combined the randomized placebo-controlled administration of oxytocin versus placebo in healthy men (n = 144) with fMRI-based resting-state functional connectivity to determine the modulatory role of oxytocin on the major basal ganglia pathways. Oxytocin specifically increased connectivity between ventral striatal and pallidal nodes with upstream frontal regions, whereas it decreased the strengths of downstream pathways between the dorsal striatum and posterior cerebellum. These pathways have previously been implicated in salience, reward and behavioral flexibility, thus shaping goal-directed behavior. Given the importance of aberrant striatal intrinsic organization in autism, addiction and schizophrenia the present findings may suggest new mechanistic perspectives for the therapeutic potential of oxytocin in these disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 184, 1 January 2019, Pages 781-789
نویسندگان
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