Antioxidant, anti-hyperlipidemia and hepatic protection of enzyme-assisted Morehella esculenta polysaccharide

The aims of this work were to investigate the antioxidant, anti-hyperlipidemia and hepatic protection of Morehella esculenta polysaccharide (MPS) from fruiting body and its enzyme-assisted MPS (EnMPS). The in vitro scavenging rates of EnMPS at 600 mg/L on superoxide, hydroxyl and 1,1‑diphenyl‑2‑pyrazole hydrazide (DPPH) radicals were 76.92 ± 2.61%, 66.74 ± 2.56% and 75.78 ± 2.4%, higher than those of MPS, respectively. Animals experiments showed that the EnMPS exhibited superior abilities of reducing hepatic lipid levels by monitoring the serum enzyme activities (ALP, ALT, ALB and AST) and serum lipid levels (CK, TC, TG, HDL-C, LDL-C and LDH), enhancing the hepatic antioxidant enzymes (FFA, SOD, CAT and T-AOC) and decreasing the lipid peroxidation (MDA and MPO). The results suggested that the EnMPS can act as a natural candidate for developing drugs to reduce blood lipids, resist oxidation and protect the liver.