کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11026820 | 1666346 | 2019 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mechanically-enhanced polysaccharide-based scaffolds for tissue engineering of soft tissues
ترجمه فارسی عنوان
داربست های مبتنی بر مکانیکی پلی ساکارید برای مهندسی بافت از بافت نرم
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کلمات کلیدی
کیتوزان، کسانتان، سورفاکتانت، سیلیکون، ویژگی های مکانیکی، مهندسی بافت،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
چکیده انگلیسی
Collagen-based materials are probably among the most used class of biomaterials in tissue engineering and regenerative medicine. Although collagen is often privileged for providing a suitable substrate on which cells can be cultured or a matrix in which cells can be dispersed, its mechanical properties represent a major limitation for clinical translation and even for handling of the obtained regenerated tissue. In this work, the combination of polysaccharides chitosan (Ch) and xanthan gum (X) was investigated as an alternative for scaffolds for soft tissue engineering. Moreover, in an attempt to reach a compromise between obtaining highly porous biomaterials while maintaining appropriate mechanical properties, a surfactant (Kolliphor® P188, K) was added to Ch-X matrices to generate pores, while silicone rubber (Silpuran® 2130A/B, S) was used to balance their mechanical properties. Addition of K (10 or 25% w/w) increased the porosity and pore-dimensions, while addition of S improved by up to 156% and 85% the elastic moduli and the elastic behavior of Ch-X-based scaffolds, under both compressive and tensile loads, respectively, at 50% strain. Relaxation tests confirmed that these materials do have a viscoelastic behavior. The presence of S increased thickness and microscale surface roughness and did not affect liquid uptake and stability, thrombogenicity, biodegradation and cytotoxicity of polysaccharide-based scaffolds. In conclusion, this work shows that Ch-X-S porous blends constitute suitable scaffolds for soft tissue engineering.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 94, 1 January 2019, Pages 364-375
Journal: Materials Science and Engineering: C - Volume 94, 1 January 2019, Pages 364-375
نویسندگان
Renata Francielle Bombaldi de Souza, Fernanda Carla Bombaldi de Souza, Cristiano Rodrigues, Bernard Drouin, Ketul C. Popat, Diego Mantovani, Ãngela Maria Moraes,