کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11030533 | 1646278 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated DSN1 expression is associated with poor survival in patients with hepatocellular carcinoma
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کلمات کلیدی
GEODFSTCGAGEPIAHCC - HCCsurvival analysis - آنالیز بقاءThe cancer genome atlas - اوتومتر ژنوم سرطانImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیdisease-free survival - بقاء بدون بیماریoverall survival - بقای کلGene Expression Profiling Interactive Analysis - تجزیه و تحلیل تعاملی پروفایل بیانCancer - سرطانprognosis - پیش شناخت بیماریGene Expression Omnibus - ژن بیان OmnibusHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dosage suppressor of Nnf1 (DSN1) is a component of the kinetochore protein complex that is required for proper chromosome segregation. Some studies have explored that DSN1 is related to colorectal cancer progression. However, the role of DSN1 in hepatocellular carcinoma (HCC) remains unknown. This study aimed to explore DSN1 expression in HCC tissues. We obtained data from The Cancer Genome Atlas and Gene Expression Omnibus to analyze DSN1 expression in HCC. DSN1 mRNA expression was assessed in 30 pairs of HCC samples via reverse-transcription quantitative polymerase chain reaction. Immunohistochemical analysis of 95 HCC tissue specimens was performed to assess DSN1 expression and examine the clinicopathological characteristics of DSN1 in HCC. Results showed that DSN1 was upregulated in HCC tissues and was strongly associated with sex (P = .031), α-fetoprotein (P < .001), tumor size (P = .032), tumor nodule number (P = .028), cancer embolus (P = .011), and differentiation grade (P = .001). Moreover, Kaplan-Meier and Cox proportional-hazards analyses indicated that high DSN1 expression was related to poor HCC patient survival and that DSN1 can serve as an independent prognostic factor for overall survival and disease-free survival. In conclusion, our findings indicate that DSN1 could serve as a novel prognostic biomarker for HCC patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 81, November 2018, Pages 113-120
Journal: Human Pathology - Volume 81, November 2018, Pages 113-120
نویسندگان
Chengjun MD, Shanzhou MD, Weiqiang MD, PhD, Yuchen MD, Ziming MD, Youjie MD, Linwei MD, PhD, Xiaoshun MD, PhD,