کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1144897 | 957439 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The analysis of tumorigenicity data using a frailty effect
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موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
آمار و احتمال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In animal tumorigenicity data, the time of occurrence of the tumor is not observed because the existence of the tumor is looked for only at either the time of death or the time of sacrifice of the animal. Such an incomplete data structure makes it difficult to investigate the impact of treatment on the occurrence of tumors. A three-state model (no tumor–tumor–death) is used to model events that occurred sequentially and to connect them. In this paper, we also employed a frailty effect to model the dependency of death on tumor occurrence. For the inference of parameters, an EM algorithm is considered. The method is applied to a real bladder tumor data set and a simulation study is performed to show the behavior of the proposed estimators.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Korean Statistical Society - Volume 40, Issue 3, September 2011, Pages 281–290
Journal: Journal of the Korean Statistical Society - Volume 40, Issue 3, September 2011, Pages 281–290
نویسندگان
Yang-Jin Kim, Chung Mo Nam, Youn Nam Kim, Eun Hee Choi, Jinheum Kim,