کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1148795 957851 2006 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Asymptotics of adaptive design with two alternating generating matrices
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
Asymptotics of adaptive design with two alternating generating matrices
چکیده انگلیسی
In the application of generalized Pólya urn (GPU) model to designs of clinical trials, in contrast to the classical homogeneous models, it is more realistic to assume nonhomogeneous generating matrices. However, in literature, due to mathematical difficulties, the generating matrices are either assumed to be homogeneous or asymptotically homogeneous (see Bai and Hu, 1999). In the present paper, we consider a new model which uses two alternating generating matrices. The theoretical results show that the asymptotics still hold in this nonhomogeneous case. Moreover, the simulation results also support the theoretical conclusions. Furthermore, this model provides a starting point for the future study of adaptive designs with non-convergent generating matrices.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 136, Issue 11, 1 November 2006, Pages 4043-4058
نویسندگان
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