کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1150656 957971 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A nonparametric test for similarity of marginals-With applications to the assessment of population bioequivalence
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
A nonparametric test for similarity of marginals-With applications to the assessment of population bioequivalence
چکیده انگلیسی
In this paper we suggest a completely nonparametric test for the assessment of similar marginals of a multivariate distribution function. This test is based on the asymptotic normality of Mallows distance between marginals. It is also shown that the n out of n bootstrap is weakly consistent, thus providing a theoretical justification to the work in Czado, C. and Munk, A. [2001. Bootstrap methods for the nonparametric assessment of population bioequivalence and similarity of distributions. J. Statist. Comput. Simulation 68, 243-280]. The test is extended to cross-over trials and is applied to the problem of population bioequivalence, where two formulations of a drug are shown to be similar up to a tolerable limit. This approach was investigated in small samples using bootstrap techniques in Czado, C., Munk, A. [2001. Bootstrap methods for the nonparametric assessment of population bioequivalence and similarity of distributions. J. Statist. Comput. Simulation 68, 243-280], showing that the bias corrected and accelerated bootstrap yields a very accurate and powerful finite sample correction. A data example is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 137, Issue 3, 1 March 2007, Pages 697-711
نویسندگان
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