کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11726 755 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Delivery of dexamethasone, ascorbate, and growth factor (TGF β-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Delivery of dexamethasone, ascorbate, and growth factor (TGF β-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes
چکیده انگلیسی

The aim of this study was to assess the efficacy of poly(N-isopropylacrylamide-co-acrylic acid) (p(NiPAAm-co-AAc)) as an injectable drug delivery vehicle and a cell therapeutic agent in the form of a supporting matrix for the chondrogenic differentiation of rabbit chondrocytes. The p(NiPAAm-co-AAc) hydrogel itself without specific differentiation-inducing drugs was used as a control in order to determine the effects of these materials on chondrogenic differentiation. The level of cartilage associated extracellular matrix (ECM) proteins was examined by immunohistochemical staining for collagen type II as well as Safranin-O and Alcian blue (GAG) staining. These results highlight the potential of a thermo-reversible hydrogel mixed with chondrocytes and differentiation materials as an injectable delivery vehicle for use in neocartilage formation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 35, December 2006, Pages 5951–5957
نویسندگان
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