کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1185514 963408 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The clinical and immunomodulatory effects of green soybean extracts
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The clinical and immunomodulatory effects of green soybean extracts
چکیده انگلیسی

The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases.


► Green soybean extract regulate the production of BAFF and APRIL in mouse spleen cells.
► Green soybean extract suppressed the TDI-induced nasal mucosa secretion.
► The symptom scores for pollinosis were improved by the green soybean extract.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 138, Issue 4, 15 June 2013, Pages 2300–2305
نویسندگان
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