کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1186390 963438 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel
چکیده انگلیسی

In traditional Chinese medicine, dried citrus fruit peels are widely used as remedies to alleviate some respiratory inflammatory syndromes and are considered as potential sources of anti-inflammatory components. Seven citrus fruits were selected for this study. We determined the inhibitory ability of citrus peel extracts on the production of pro-inflammatory mediators, prostaglandin E2 (PGE2) and nitric oxide (NO), in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Among the tested citrus peels, Ponkan (Citrus reticulata Blanco) and Tonkan (Citrus tankan Hayata) deserve special attention due to their outstanding inhibitory effect on PGE2 and NO secretion. We have also examined the composition, flavanone glycosides and polymethoxy flavones. The polymethoxy flavone content, especially nobiletin, appears to correlate well with the anti-inflammatory activities of certain citrus peel extracts. Thus, our results suggest that polymethoxy flavones contribute crucially to the anti-inflammatory activity of citrus peels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 119, Issue 3, 1 April 2010, Pages 868–873
نویسندگان
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