کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1186709 963446 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch
چکیده انگلیسی

Curcumin is a natural polyphenolic compound with anti-oxidation, anti-inflammation, and anti-cancer properties. However, these benefits of curcumin suffer from its extremely low water solubility and bioavailability. In this study, we demonstrated that hydrophobically modified starch (HMS), a food-grade biopolymer, is able to form micelles and to encapsulate curcumin. Upon encapsulation, curcumin showed increased solubility by about 1670-folds. This may be due to the hydrophobic interaction and hydrogen bonding between curcumin and HMS, as suggested by results from infrared and fluorescence spectroscopy. The synchrotron small-angle X-ray scattering results indicated that the addition of curcumin did not alter the structure of HMS, whose radius of gyration remained at 14.1 ± 0.1 nm. Moreover, encapsulated curcumin revealed enhanced in vitro anti-cancer activity compared to free curcumin. This study provides a novel food-grade encapsulation formulation to increase the bioaccessibility of curcumin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 119, Issue 2, 15 March 2010, Pages 669–674
نویسندگان
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