Highly selective differential pulse voltammetric determination of warfarin in pharmaceutical and biological samples using MnFe2O4/MWCNT modified carbon paste electrode

• A Spinel-structured MnFe2O4 nanoparticles were synthesized by precipitation method.
• The structure of the MnFe2O4 was characterized by using XRD, FE-SEM and FT-IR.
• A novel warfarin sensor has been developed based on MWCNTs modified with MnFe2O4.
• -The proposed electrode was very easy to fabricate and eco-friendly for analysis.

A chemically modified electrode was prepared by incorporating MnFe2O4 into multi-walled carbon nanotubes paste matrix (MWCNTs/MnFe2O4/CPE) to determine warfarin. Cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of warfarin at the chemically modified electrode. According to the results, MWCNTs/MnFe2O4/CPE showed high electrocatalytic activity for warfarin oxidation, producing a sharp oxidation peak current at about + 0.91 vs Ag/AgCl reference electrode at pH 4.0. The peak current was linearly dependent on warfarin concentration over the range of 0.10–447.0 μmol L− 1 with the detection limit (3σ) of 0.08 μmol L− 1. The proposed method was successfully applied as a rapid, highly selective, simple, and precise one to determine warfarin in biological fluids.

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