کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1227834 | 968436 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Room-temperature phosphorimetry for the determination of trace contaminations of camptothecin in anticancer drugs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Room-temperature phosphorimetry for the determination of trace contaminations of camptothecin in anticancer drugs Room-temperature phosphorimetry for the determination of trace contaminations of camptothecin in anticancer drugs](/preview/png/1227834.png)
چکیده انگلیسی
Campthotecin derivatives, irinotecan (CPT-11) and topotecan (TPT), have been used for the treatment of cancer and camptothecin (CPT) is a potential contaminant in these anticancer medicines. In this work, room-temperature phosphorimetry was used to quantify either CPT as trace contaminants in anticancer drugs and CPT-11 as the main ingredient in anticancer medicines. Phosphorescence from CPT-11 was induced using Pb(NO3)2 in SDS treated cellulose substrate while CPT was selectively detected using TlNO3 as a phosphorescence enhancer in either cellulose or nylon substrates. The limit of quantification for CPT and CPT-11 was in ng order. A detailed metrological study was made to calculate the combined uncertainty associated to the CPT phosphorescence measurement. Satisfactory analyte recoveries were obtained for CPT-11 as a main active ingredient of a pharmaceutical formulation. The selective determination of CPT in a matrix containing TPT was made using the higher order (2nd) derivative of the excitation spectra. The results demonstrated the applicability of the method due its simplicity, cost effectiveness and selectivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microchemical Journal - Volume 96, Issue 1, September 2010, Pages 108-113
Journal: Microchemical Journal - Volume 96, Issue 1, September 2010, Pages 108-113
نویسندگان
Priscila M.S. Maia, Alessandra Licursi M.C. da Cunha, Flávia F. de C. Marques, Ricardo Q. Aucelio,