Size controlled biogenic silver nanoparticles as antibacterial agent against isolates from HIV infected patients

• Size controlled synthesis of silver nanoparticles from Spirulina platensis.
• Bacterial pathogens from samples of HIV infected patients identified by 16S rRNA sequencing.
• Antibacterial efficacy against clinical isolates from HIV infected patients.

Silver nanoparticles (AgNPs) are synthesized using biological sources due to its high specificity in biomedical applications. Herein, we report the size and shape controlled synthesis of AgNPs using the aqueous extract of blue green alga, Spirulina platensis. Size, shape and elemental composition of AgNPs were characterized using UV–vis spectroscopy, Fluorescence spectroscopy, FT-IR (Fourier Transform-Infrared Spectroscopy), FT-RS (Fourier Transform-Raman Spectroscopy), SEM–EDAX (Scanning Electron Microscopy–Energy Dispersive X-ray analysis) and HR-TEM (High Resolution Transmission Electron Microscopy). AgNPs were stable, well defined and monodispersed (spherical) with an average size of 6 nm. The synthesized AgNPs were tested for its antibacterial potency against isolates obtained from HIV patients.

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