کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1228916 | 1495210 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Spectrophotometric method to simultaneous determination of benznidazole and itraconazole
• Analysis of mixtures was performed in order to enable selectivity.
• Robust, linear and precise method with low detection and quantification limits
• The method is useful for quality control of pharmaceutical dosage form.
The aim of this work was the development of an analytical procedure using spectrophotometry for simultaneous determination of benznidazole (BNZ) and itraconazole (ITZ) in a medicine used for the treatment of Chagas disease. In order to achieve this goal, the analysis of mixtures was performed applying the Lambert–Beer law through the absorbances of BNZ and ITZ in the wavelengths 259 and 321 nm, respectively. Diverse tests were carried out for development and validation of the method, which proved to be selective, robust, linear, and precise. The lower limits of detection and quantification demonstrate its sensitivity to quantify small amounts of analytes, enabling its application for various analytical purposes, such as dissolution test and routine assays. In short, the quantification of BNZ and ITZ by analysis of mixtures had shown to be efficient and cost-effective alternative for determination of these drugs in a pharmaceutical dosage form.
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Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 159, 15 April 2016, Pages 48–52