Photophysical and photochemical studies of a novel amphiphilic zinc phthalocyanine and its interaction with calf thymus DNA

• A novel amphiphilic zinc phthalocyanine was synthesized.
• The synthesized phthalocyanine has high photodynamic activity.
• The synthesized phthalocyanine has strong affinity to calf thymus DNA.
• The synthesized phthalocyanine shows excellent photo-induced damage activity to calf thymus DNA.

β-tetra (aminophenoxy) sulfonic substituted zinc phthalocyanines (SNZnPc), a novel amphiphilic zinc phthalocyanine (Pc), was synthesized. The photophysical, photochemical, and photobiology properties were studied. Results indicated that the synthesized SNZnPc has good amphiphilic property and high reactive oxygen species (ROSs) generation ability. Furthermore, SNZnPc has strong affinity to calf thymus DNA (CT-DNA) through intercalation ways and can effectively cleavage CT-DNA after irradiation by light with appropriate wavelength.

A novel amphiphilic zinc phthalocyanine was synthesized. The photophysical, photochemical and photobiology property were studied, which indicated that the synthesized SNZnPc has good amphiphilic property, high reactive oxygen species generation capacity, strong affinity to CT-DNA through intercalation interaction mode and effective photo-induced cleavage activity to CT-DNA.Figure optionsDownload as PowerPoint slide