کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1229184 1495227 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and characterization of 2-substituted benzimidazoles and their evaluation as anticancer agent
ترجمه فارسی عنوان
سنتز و خصوصی سازی بنزیدیمازول های 2-جایگزین و ارزیابی آنها به عنوان عامل ضد سرطان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Synthesis of benzimidazoles derivatives.
• X-ray crystal structure.
• DNA binding studies.
• Anticancer activities.

In this work, we report a series of benzimidazole derivatives synthesized from benzene-1,2-diamine and aryl-aldehydes at room temperature. The synthesized compounds have been characterized on the basis of elemental analysis and various spectroscopic studies viz., IR, 1H- and 13C-NMR, ESI-MS as well by X-ray single X-ray crystallographic study. Interaction of these compounds with CT-DNA has been examined with fluorescence experiments and showed significant binding ability. All the synthesized compounds have been screened for their antitumor activities against various human cancer cell lines viz., Human breast adenocarcinoma cell line (MCF-7), Human leukemia cell line (THP-1), Human prostate cancer cell lines (PC-3) and adenocarcinomic human alveolar basal epithelial cell lines (A-549). Interestingly, all the compounds showed significant anticancer activity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 142, 5 May 2015, Pages 286–291
نویسندگان
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