Synthesis, characterization and antibacterial activity of a tridentate Schiff base derived from cephalothin and sulfadiazine, and its transition metal complexes

• A new Schiff base using cephalothin antibiotic was prepared.
• Cephalothin Schiff base transition metal complexes were prepared.
• Magnetic and spectroscopic properties, and antibacterial activity were studied.

Metal(II) coordination compounds of a cephalothin Schiff base (H2L) derived from the condensation of cephalothin antibiotic with sulfadiazine were synthesized. The Schiff base ligand, mononuclear [ML(H2O)3] (M(II) = Mn, Co, Ni, Zn) complexes and magnetically diluted dinuclear copper(II) complex [CuL(H2O)3]2 were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalothin Schiff base ligand H2L behaves as a dianionic tridentate NOO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.

Transition coordination compounds with a Schiff base (H2L) derived from the condensation of cephalothin antibiotic with sulfadiazine were synthesized, characterized and screened for antibacterial activity.Figure optionsDownload as PowerPoint slide