Coordination behavior and bio-potent aspects of Ni(II) with 2-aminobenzamide and some amino acid mixed ligands – Part II: Synthesis, spectral, morphological, pharmacological and DNA interaction studies

• Mixed ligand complexes show significant therapeutic and enzymatic actions.
• Ortho substituted benzamide and its derivatives are efficient FXa inhibitors.
• Ni(II) complexes show homogeneous morphology with microcrystalline nature.
• Pharmacological evaluations of the complexes show higher inhibiting activities.
• Ni(II) complexes show remarkable DNA binding and oxidative cleavage activities.

A series of novel bioactive mixed ligand Ni(II) complexes (1a–1d) have been synthesised by using 2-aminobenzamide (2AB) and some bio-relevant amino acid ligands. The synthesised Ni(II) complexes were structurally characterized by various physico-chemical and spectral studies. Elemental analysis and molar conductance values suggest that 1:1:1 stoichiometry with non-electrolytic nature. Based on the spectral studies, both the ligands act as bidentate and they chelate with Ni(II) ion via amino-NH2 and amido-O and deprotonated carboxylato-O and amino-NH2 atoms respectively to form a stable six, five membered chelate rings with mononuclear octahedral geometry. Thermal studies show the presence of coordinated water and acetate molecules in the coordination. The powder X-ray diffractogram and SEM pictograph imply that all the complexes have fine crystalline peaks with homogeneous surface morphology. In vitro antimicrobial and antioxidant studies indicate the complexes are more active than free 2-aminobenzamide ligand. The Ni(II)-2AB-gly/phe complexes (1a and 1d) show significant oxidative cleavage and DNA binding activities. Moreover, the 3D molecular modeling, analysis of the complexes has also been studied.

A series of novel bioactive mixed ligand Ni(II) complexes (1a–1d) have been synthesised from 2-aminobenzamide (2AB) with some amino acids and structurally characterized by various physico-chemical and spectral studies. Based on the spectral studies, both the ligands act as bidentates and they chelate with Ni(II) ion to form a stable six, five membered chelate ring with octahedral geometry. The powder X-ray diffractogram and SEM pictograph studies imply all the complexes have microcrystalline with homogeneous surface morphology. In vitro antimicrobial and antioxidant studies of Ni(II) complexes showed significant activities than free 2-aminobenzamide. The Ni(II)-2AB-gly/phe complexes show significant oxidative DNA cleavage and binding activities.Figure optionsDownload as PowerPoint slide