Synthesis, spectroscopic, anticancer and antibacterial studies of Ni(II) and Cu(II) complexes with 2-carboxybenzaldehyde thiosemicarbazone

• Synthesis and spectral characterizations of novel Schiff base ligand (2CBTS).
• Preparation and spectral studies of Ni(II) and Cu(II) complexes of 2CBTS.
• Antibacterial screening of ligand, Ni(II) and Cu(II) complexes.
• Anticancer studies of 2CBTS and its Cu(II) complexes against MCF 7.

Ni(II) and Cu(II) complexes of 2-carboxybenzaldehyde thiosemicarbazone (L) were synthesized and investigated by their spectral and analytical data. These newly synthesized complexes have a composition of M(L)X(H2O)2 (where M = Ni(II), Cu(II) and X = Cl−, NO3-, CH3COO−) and (L) is the tridentate Schiff base ligand. The ligand and its complexes have been characterized on the basis of analytical, molar conductivity, magnetic susceptibility measurements, FT-IR, ESR, 1H NMR and electronic spectral analysis. All the compounds were non-electrolytic in nature. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) and a tetragonal geometry for Cu(II) complexes. The ligand and its metal complexes were screened for their anticancer studies against human breast cancer cell lines MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby–Bauer single disk susceptibility test.

Tridentate Schiff base ligand 2-carboxybenzaldehyde thiosemicarbazone (L) and its Ni(II) and Cu(II) complexes were synthesized and characterized with spectral data. Synthesized complexes have a composition of M(L)X(H2O)2 (where M = Ni(II), Cu(II) and X = Cl−, NO3-, CH3COO−). Spectral studies reveals, an octahedral geometry for Ni(II) and a tetragonal geometry for Cu(II) complexes. Compounds were screened for anticancer studies against MCF-7 and calculated minimum inhibitory concentration and also for antibacterial activity using Kirby–Bauer single disk susceptibility test.Figure optionsDownload as PowerPoint slide