FTIR spectroscopic comparison of serum from lung cancer patients and healthy persons

• IR spectra of lung cancer patients’ and healthy persons’ serum were investigated.
• IR spectra of malignant serum and healthy serum were similar.
• A1080/A1170 might be potentially useful for identifying malignant and healthy serum.
• The protein secondary structure was different between malignant and healthy serum.
• FTIR spectroscopy can indentify serum from lung cancer patients and healthy persons.

The incidence and mortality of lung cancer remains so high that it is very urgent to develop an effective method for early detection of lung cancer. Serum can reflect physiological and pathological changes of human body, so FTIR spectroscopy was used to compare lung cancer patients’ and healthy persons’ serum in this study. The A1080/A1170 ratio might be potentially useful for distinguishing lung cancer patients’ serum from healthy persons’ serum. Moreover, the result of curve fitting indicated that the ratios of α-helix/antiparallel β-sheet were lower for lung cancer patients’ serum than those for healthy persons’ serum. These results indicated that IR spectra of serum might be potentially useful for detecting lung cancer.

IR spectra of lung cancer patients’ serum (A) and healthy persons’ serum (B) were compared.Figure optionsDownload as PowerPoint slide