Molecular recognition study of Carbamazepine, antiseizure drug, by p-t-butyl calix(8)arene

• Molecular recognition study of the drug molecule,carbamazepine.
• Supramolecule p-t-butyl calix (8) arene was used as host molecule.
• Thermodynamic property of the host-guest complexes formed has been studied.

The formation of inclusion complex of Carbamazepine, a antiseizure drug molecule, with the supra molecule, p-t-butyl calix(8)arene was studied. p-t-Butyl calix(8)arene was the host molecule and Carbamazepine was the guest molecule. Optical absorption spectral studies were carried out to study the molecular recognition properties of p-t-butyl calix(8)arene with Carbamazepine. The stochiometry of the host–guest complex and the binding constant were determined.

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