Synthesis, thermal and spectroscopic behaviors of metal–drug complexes: La(III), Ce(III), Sm(III) and Y(III) amoxicillin trihydrate antibiotic drug complexes

• Amoxicillin trihydrate complexes were synthesized.
• Amoxicillin reacted with lanthanide metal ions by 1:1 molar ratio.
• Amoxicillin reacted with lanthanide ions as tridentate ligand.
• Thermal stability depends on electronegativities of metal ions and ionic size.

The metal complexes of Amoxicillin trihydrate with La(III), Ce(III), Sm(III) and Y(III) are synthesized with 1:1 (metal:Amox) molar ratio. The suggested formula structures of the complexes are based on the results of the elemental analyses, molar conductivity, (infrared, UV–visible and fluorescence) spectra, effective magnetic moment in Bohr magnetons, as well as the thermal analysis (TG), and characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The results obtained suggested that Amoxicillin reacted with metal ions as tridentate ligands, coordinating the metal ion through its amino, imino, and β-lactamic carbonyl. The kinetic thermodynamic parameters such as: Ea, ΔH*, ΔS* and ΔG* were estimated from the DTG curves.

Inhibition zone diameter of Amoxicillin complexes towards some kind of bacteria and fungi.Figure optionsDownload as PowerPoint slide