Transient spectra study on photo-dynamics of curcumin

• The novel mechanism of DNA damage induced by photosensitized curcumin was explored.
• The neutral radical of Cur was an identical product in photosensitized Cur by pulse radiolysis.
• Reaction rate constants between Cur and nucleic acid bases/nucleotides were determined.

A novel mechanism of DNA damage induced by photosensitized curcumin (Cur) was explored using laser flash photolysis, pulse radiolysis and gel electrophoresis. Cur neutral radical (Cur) was confirmed as an identical product in photo-sensitization of Cur by laser flash photolysis and pulse radiolysis. A series of reaction rate constants between Cur and nucleic acid bases/nucleotides were determined by pulse radiolysis. Gel electrophoresis was carried out to investigate damage induced by photosensitized Cur to biologically active DNA. The results indicate that the damage to DNA may be caused by Cur produced from the photosensitization of Cur.

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