کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1230679 | 1495261 | 2013 | 11 صفحه PDF | دانلود رایگان |

UV–Vis, 1H NMR, FT-IR, LC–MS and fluorescence spectral techniques were employed to investigate the mechanism of interaction of sulfamethoxazole with varying number of methoxy/chloro substituted 1,4-benzoquinones (MQ1–4) and to characterize the reaction products. The interactions of MQ1–4 with sulfamethoxazole (SULF) were found to proceed through the formation of a donor–acceptor complex, containing radical anion and its conversion to the product. Fluorescence quenching studies showed that the interaction between the donor and the acceptors are spontaneous. The results indicated that the progressive replacement of chlorine atom (−I effect) by methoxy group (+M effect) in the quinone decreased the electron acceptor property of the quinone. The results of the correlation of experimentally measured binding constants with electrochemical data and ab initio DFT calculations supported these observations.
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► Novel substituted 1,4-benoquinones were employed as acceptors in the CT interaction with a drug.
► The mechanism of the interaction was studied using various spectral techniques.
► Progressive replacement of Cl (−I effect) by OMe (+M effect) makes the acceptor weaker.
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 107, 15 April 2013, Pages 156–166