کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1231194 | 1495264 | 2013 | 7 صفحه PDF | دانلود رایگان |

Three simple, specific, accurate and precise spectrophotometric methods depending on the proper selection of two wavelengths are developed for the simultaneous determination of Amlodipine besylate (AML) and Atorvastatin calcium (ATV) in tablet dosage forms. The first method is the new Ratio Difference method, the second method is the Bivariate method and the third one is the Absorbance Ratio method. The calibration curve is linear over the concentration range of 4–40 and 8–32 μg/mL for AML and ATV, respectively. These methods are tested by analyzing synthetic mixtures of the above drugs and they are applied to commercial pharmaceutical preparation of the subjected drugs. Methods are validated according to the ICH guidelines and accuracy, precision, repeatability and robustness are found to be within the acceptable limit. The mathematical explanation of the procedures is illustrated.
Figure optionsDownload as PowerPoint slideHighlights
► Simple, accurate, selective and precise spectrophotometric methods.
► Collecting & comparing different methods handling dual wavelength spectrophotometry.
► Introducing and application of the new and simple Ratio Difference method.
► Rapid methods without need for sophisticated instruments or expensive solvents.
► Methods validated as per ICH guidelines, parameters found to be within the limits.
Journal: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy - Volume 104, March 2013, Pages 70–76