Spectral and Eukaryotic DNA degradation studies for Ni(II), Pd(II), Pt(IV), Cu(II) and UO22+ complexes derived from thiouracil derivative

A derivative of thiouracil ligand was prepared. Ni(II), Pd(II), Pt(IV), Cu(II) and UO22+ complexes were prepared. The elemental and different spectral tools were used for their characterization. A binegative tetradentate mode is the general coordination behavior of the ligand towards all metal ions used. The structural geometries were varied from square-planer (Pt, Pd(II)), square-pyramidal (Cu(II)) and octahedral (UO22+). The geometry optimization implementing the hyperChem reveals that the Cu(II) complex is the most stable one. The thermogravimetric analysis supports the presence of solvent molecules attached with most complexes. The biological investigation was studied on different microorganisms as gram-positive, gram-negative and fungia. The Ni(II) complex shows the most toxic activity towards most organisms used. The degradation effect of DNA was studied by the use of investigated compounds and reveal that the Ni(II) and Pd(II) complexes are the most effective on the DNA degradation.

The EPR spectrum of Cu(II) complex.Figure optionsDownload as PowerPoint slideHighlights
► A new series of complexes was prepared using different metal ions with a new derivative of thiouracil.
► The complexes were investigated using all valuable spectral and chemical tools.
► ESR spectrum of Cu(II) complex displays axially symmetric g tensor parameters indicating the square-pyramidal geometry.
► The biological effect of all investigated compounds was studied on different microorganisms.